Did You Know?

Biologics are derived from natural sources, such as platelets, bone marrow, and fat cells, and are processed to obtain concentrated doses of healing components. Platelet-Rich Plasma (PRP)*, Bone Marrow Aspirate Concentrate (BMAC), and Micro-Fat (M-Fat) are some examples of biologics used in musculoskeletal medicine. BMAC is typically sourced from the pelvis and M-Fat from the fat in the abdominal area or lower back.

Therapies using BMAC and M-Fat have previously been referred to as Stem Cell Therapy, but that term is no longer accurate, and they can simply be called Cell Therapies. This is because new research confirms these are progenitor cells that are in fact not stem cells but rather precursors to them.

Once harvested from your body, these cells are injected into a tissue. It Is believed from post-injection biopsies to pull on the “body’s drug store” to bring cells from other sources in your body to the tissue that was injected. These biopsies have shown that regardless of what is injected into these tissues, these injections may not be what is there a week or two later. Rather these injected cells stimulate the body’s response to pull from the body’s drug store—allowing a more prolonged and lasting effect.

As we venture into the realm of regenerative medicine, the potential of biologics in treating musculoskeletal conditions is truly exciting. By understanding the science, regulations, and available options, patients can make informed decisions about their healthcare journey.

Other Articles in the “Use of Biologics for Treatment of Musculoskeletal Conditions” Series:

• The Current Landscape
• Biologics as Regenerative Medicine
• The Healing Potential of Platelet-Rich Plasma
• Challenges Facing the Use of Biologics
• The Role of Exercise
• Series Summary & Takeaways

Article Series: Use of Biologics for Treatment of Musculoskeletal Conditions
From your spine and sports medicine expert Dr. Michael C. Geraci, Jr., MD PT.